O-270 Does the ‘freeze all' strategy improve the chances of birth in the presence of adenomyosis?

Abstract Study question Does the freeze all strategy improve cumulative live birth rates in infertile women affected with adenomyosis? Summary answer The adenomyosis-affected is associated significantly higher rates. What known already Controlled ovarian stimulation enhances efficacy of assisted reproductive technology (ART) by permitting multiple-oocyte yields, but also may alter endometrial receptivity an earlier development which could turn contribute to diminished pregnancy chances. Technical improvements vitrification made deferred frozen-thawed embryo transfer (freeze –all strategy) a feasible alternative fresh (ET). In adenomyosis, eutopic endometrium abnormal and its functional alterations are seen as likely quality receptivity. One adenomyosis ART-management know whether lead increase outcomes. design, size, duration This cohort study conducted tertiary care university hospital included undergoing blastocyst following vitro fertilization / intracytoplasmic sperm injection (IVF/ICSI) between 01/01/2018 31/11/2021. diagnosis was based on imaging criteria (e.g. transvaginal ultrasound and/or magnetic resonance imaging). Participants/materials, setting, methods Women who underwent were compared those ET strategy. Statistical analyses using univariate multivariate logistic regression models. primary outcome rate (LBR). Main results role chance A total 306 analysis: 111 group 195 group. phenotype (internal diffuse external focal adenomyomas) not different two groups. increased [86 (44.1%) vs. 34 (30.6%), p = 0.020]. OPR [89 (45.6%) versus 37 (33.3%), 0.035] CPR [122 (62.6%) 53 (47.7%), 0.011] group, whereas early miscarriage After analysis, significant (OR 1.85; 95% CI 1.06 – 3.24; 0.031). Limitations, reasons for caution analysis consists retrospective study. inclusion patients from referral center specialized management endometriosis constitute selection bias, these have had particularly severe forms adenomyosis. Wider implications findings be attractive option ART success rates, womenundergoing IVF/ICSI. Trial registration number NA